We Knocked the Genes out of a Zebrafish—and Other Tales | Bulletin of the Atomic Scientists

Zebrafish. Credit Azul via Wikimedia Commons

“You’re making a fish without eyeballs? What are you doing—creating some sort of Franken-fish?” That was the first response I got—which happened to come from an investigative reporter at USA Today—upon delivering the news that I was a biomedical fellow at the Logan Science Journalism Program at in Woods Hole, Massachusetts.

The second comment—also from a journalist friend, but in regard to removing the creature’s colorful spots—was: “Great. You’re transforming zebrafish into boring old guppies.”

Neither was exactly true.

Eel Pond and Marine Biological Laboratory campus.
Eel Pond and Marine Biological Laboratory campus. Credit: Dan Drollette, Jr.

Yes, I was a science journalist enrolled in a nearly two-week biomedical program last month—along with four others—at this renowned center of biological research, to get hands-on instruction in the laboratory from working biologists on how genetic editing tools like CRISPR are used.

But no, we weren’t creating Frankenstein’s monsters in fish form. 

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